HPLC: An Analytical Technique for Pharmaceutical Validation of Omeprazole

Healthcare advances have been receiving increasing attention since the last few decades. Several fatal and clinically tough physiological complications such as cancer, diabetes, cardiovascular complications, malformations or improper coordination of brain with rest of the body, have been the major thrust areas that have kept the molecular biologists at bay and forced them to continuously ponder over the drug synthesis strategic mechanisms. In this context, omeprazole is the drug frequently used to treat the excess acidity of gastrointestinal region of living organisms. The commercial synthesis of this and related generic drugs has been a topic of concern because this involves multiple steps and a throughput screening of the synthesized intermediates before the final drug extraction actually takes place. This review article highlights the purification, characterization and validation strategies of drug omeprazole and its associated intermediates, which have a very sharp influence on the nature of drug synthesized. The characterization and testing techniques such as those of High Pressure liquid Chromatography (HPLC), spectroscopic analysis have also been discussed.